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M9490415.TXT
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1994-09-19
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Document 0415
DOCN M9490415
TI Murine AIDS is an antigen-driven disease: requirements for major
histocompatibility complex class II expression and CD4+ T cells.
DT 9411
AU Giese NA; Giese T; Morse HC 3rd; Laboratory of Immunopathology, National
Institute of Allergy and; Infectious Diseases, Bethesda, Maryland 20892.
SO J Virol. 1994 Sep;68(9):5819-24. Unique Identifier : AIDSLINE
MED/94335098
AB Murine AIDS (MAIDS) is a complex syndrome of lymphoproliferation and
immunodeficiency induced by a replication-defective murine leukemia
virus (BM5def) that encodes Pr60gag as its only product. It has been
suggested that the gag polyprotein is responsible for vigorous antigenic
stimulation of CD4+ T cells and generalized secondary activation of the
immune system. This model was tested first by infecting mice (C2K/O)
that lack class II major histocompatibility complex molecules required
for presentation of antigens to CD4+ T cells. C2K/O mice expressed
BM5def at high levels but did not develop MAIDS either when
unmanipulated or following transfer of CD4+ T cells. Second, B6 mice
reconstituted with C2K/O bone marrow cells had normal frequencies of B
cells (class II negative) and CD4+ cells and expressed high levels of
BM5def transcripts but did not develop MAIDS; however, MAIDS developed
in class II-competent nu/nu mice reconstituted with CD4+ T cells and in
C2K/O mice reconstituted with B6 bone marrow to give class II-positive B
cells and with purified CD4+ T cells. These results indicate that
induction of MAIDS by BM5def is antigen driven and is dependent on
expression of major histocompatibility complex class II molecules on
antigen-presenting cells and the presence of CD4+ T cells.
DE Animal Antigens, Surface/ANALYSIS Base Sequence DNA Primers/CHEMISTRY
Histocompatibility Antigens Class II/*IMMUNOLOGY Leukemia Viruses,
Murine/GROWTH & DEVELOPMENT/IMMUNOLOGY/ *PATHOGENICITY Lymphocyte
Transformation Membrane Glycoproteins/ANALYSIS Mice Mice, Inbred
C57BL Mice, Nude Molecular Sequence Data Murine Acquired
Immunodeficiency Syndrome/*IMMUNOLOGY Mutagenesis, Site-Directed
Structure-Activity Relationship Support, Non-U.S. Gov't Support, U.S.
Gov't, P.H.S. T-Lymphocyte Subsets/IMMUNOLOGY T4
Lymphocytes/*IMMUNOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).